You have to envy David Byrne. He’s become a kind of roaming intellectual, writing about bicycling or lecturing about music. In this thought-provoking TED talk he makes a pretty convincing case for context-driven content. Musicians, artists, and authors instinctively create work for the venue (physical or otherwise) in which it will be regarded.
The publishing analogue for this is, naturally, ebooks. There have been several studies already how screen-based reading changes online content; similarly, how will fiction change for ereaders in the coming years and decades? I suppose we won’t be able to parse such changes until much later, looking backward. Still interesting though.